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中药制剂“归芎益母散”的质量标准研究
吴雪琴,孙研,王胜义,王磊,吴亮红,岳鹏,崔东安
0
(中国农业科学院兰州畜牧与兽药研究所)
摘要:
目的:研究“归芎益母散”的质量标准,为控制产品质量做奠基。方法:采用薄层色谱法对归芎益母散中的益母草、红花、当归、川芎定性鉴别研究、使用ELSD对盐酸水苏碱进行定量鉴别研究。结果:定性鉴别结果图中,益母草、红花、当归、川芎的斑点清晰,专属性强;定量鉴别结果图归芎益母散阴性对照无干扰,方法具有专一性。盐酸水苏碱在0.0507~0.8115 mg/mL (r2=0.9996)的范围内与峰面积的外标对数呈良好的线性。加样回收率107.15%,RSD为1.90%。结论:本研究所建立的方法操作简单,重现性好,准确可靠,所建立的标准可以有效控制“归芎益母散”的质量。
关键词:  归芎益母散  定性鉴别  盐酸水苏碱定量鉴别  
DOI:
投稿时间:2021-01-12修订日期:2021-06-01
基金项目:农产品质量安全监管(2130109);宁夏回族自治区重点研发项目(2019BEF02003);兰州市人才创新创业项目(2018-RC-91)
Study on the quality standard of Gui Xiong Yi Mu San
(Lanzhou Institute of Husbandry and PHarmaceutical Sciences)
Abstract:
Objective: to study the quality standard of "Guixiong Yimu powder" and lay a foundation for the quality control of the product. Methods: Leonurus Japonicus, Safflower, Angelica Sinensis and ligusticum Chuanxiong in Guixiong Yimusan were identified by Thin layer chromatography, and stachydrine hydrochloride was identified by ELSD. Results: the spots of Leonurus japonicus, safflower, Angelica Sinensis and ligusticum Chuanxiong were clear and the specificity was strong in the results of qualitative identification. Stachydrine hydrochloride showed a good linear relationship with the external standard logarithm of peak area in the range of 0.0507~0.8115 mg/mL (R2 = 0.9996) . The recovery was 107.15% , RSD was 1.90% . Conclusion: The method established in this study is simple, reproducible, accurate and reliable, the established standard can effectively control the quality of "Guixiong Yimu powder" .
Key words:  Guixiong Yimu powder  qualitative identification  Quantitative identification of Stachydrine Hydrochloride  

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