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HPLC-PDA联合UPLC-Triple TOF MS法确证恩诺沙星注射液中的非法添加物
宋慧敏,熊玥,汪云花,孙瑶,石慧慧
0
(江苏省兽药饲料质量检验所)
摘要:
对恩诺沙星注射液中非法添加加替沙星的确证。通过HPLC-PDA法初筛发现1批恩诺沙星注射液中含有非法添加物,利用高分辨质谱对未知物进行筛查,推测出非法添加物为加替沙星,并用进行确证。结果显示,该批样品中的非法添加物为加替沙星。本研究为兽药中非法添加物筛查及定性确证提供了一个有效的思路与方法。
关键词:  恩诺沙星注射液  非法添加  加替沙星  确证  UPLC-Triple TOF MS  HPLC-PDA
DOI:
投稿时间:2021-01-28修订日期:2021-07-08
基金项目:
Identification of Illegal Additive in Enrofloxacin Injection by UPLC-Triple TOF MS and HPLC-PDA Method
(Jiangsu Testing Institute of Veterinary Drug and Feed)
Abstract:
To confirm the illegal addition of gatifloxacin in enrofloxacin injection. One batch of enrofloxacin injection was found containing illegal additive by HPLC-PDA. The unknown substance was screened by high-resolution mass spectrometry. It was speculated that the illegal additive was gatifloxacin, and confirmed by UPLC-TripleTOF MS and HPLC-PDA. The results showed that the illegal additive in this batch of enrofloxacin injection was gatifloxacin. This study provides an effective ideas and method for the illegal additives qualitative analysis in veterinary drugs.
Key words:  enrofloxacin injection  illegal addition  gatifloxacin  UPLC-TripleTOF MS  HPLC-PDA

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