| 摘要: |
| 减毒沙门氏菌能诱导粘膜、体液及细胞免疫，其不仅自身产生免疫效应，而且能够携带外源基因诱导宿主特异性应答，是具有广泛应用前景的疫苗载体。本文从减毒致弱菌株构建、外源基因高效表达等方面综述了减毒沙门氏菌载体构建策略的新进展，最后对减毒沙门氏菌活载体应用中待解决的问题进行归纳。 |
| 关键词: 减毒沙门氏菌 载体 构建策略 |
| DOI： |
| 投稿时间：2013-10-29修订日期：2013-12-27 |
| 基金项目:北京市科技新星计划(xx2013099) |
|
| The progress of the vector construction of attenuated Salmonella |
|
| (Beijing Vocational College of Agriculture) |
| Abstract: |
| Attenuated Salmonella can induce mucosal, humoral and cellular immune responses. Salmonella can present antigen, stimulate specific humoral and cellular immune response against both Salmonella and heterologous antigen. So that Salmonella is considered as prospective vaccine vector. In this review, the strategy for constructions of attenuated Salmonella vector is described, including the attenuated Salmonella strains, high level expression of heterologous antigen, etc. At the end, it is prospected about the problems to be solved during the application of attenuated Salmonella vector. |
| Key words: Attenuated Salmonella vector construction |
