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参金口服液大鼠亚慢性毒性试验研究
丁俊仁,梁歌
0
(四川省畜牧科学研究院)
摘要:
为评价参金口服液的安全性,采用Sprague Dawley (SD)大鼠开展了亚慢性毒性试验。120只SD大鼠(雌雄各半)随机分为高、中、低剂量和空白对照组,药物组分别按64、32、16 g /kg体重灌胃给药,空白对照组给予同体积蒸馏水,连续给药28天,停药后观察14天。结果表明,高剂量组出现谷丙转氨酶升高,停药后可恢复正常,其余相关检测指标均未见异常。表明参金口服液在临床应用是安全的。
关键词:  参金口服液  大鼠  亚慢性毒性
DOI:
投稿时间:2017-03-18修订日期:2017-12-07
基金项目:四川省基本科研项目(SASA2015A17);四川省财政运行专项(SASA2014CZYX010)
Subacute toxicity test of Shenjin oral liquid in rat
(Sichuan Animal Science Academy,Chengdu Sichuan)
Abstract:
To evaluate the safety of Shenjin oral liquid (SJ) in animal model, we performed the subchronic toxicity test using Sprague Dawley rats. A total of 120 rats were randomly divided into 4 groups (experimental groups: high, medium, low dose groups, and control group). For experimental groups the SJ was administrated once daily by oral gavage at doses of 16, 32, and 64 g/kg, while distilled water was given to rats in the control group. Administration was consecutive for 28 days. The main outcome measures including reversibility, persistence, or delayed occurrence of toxic effects were observed during the period of administration and within 14 days after withdrawal. Compared with the control group, ALT was significant increased (p<0.05) in the high dose group, while other parameters were normal. The effect of toxicity would recover after drug withdrawal. Our results indicated that administration of SJ was safe in SD rats, suggesting potential safe use in clinic.
Key words:  Shenjin oral liquid  SD rat  subacute toxicity.

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