| 摘要: |
| 为优化恩拉霉素提取工艺，以70%甲醇溶液为提取剂，提取恩拉霉素，经过浓缩、脱色、结晶、重结晶，制备高含量恩拉霉素产品。得到最佳提取工艺条件是：浸提pH3.5~4.0，浸提温度30 ℃，三次浸提时间1 h，一次浸提料液比1∶7，二次浸提料液比1∶3，三次浸提料液比1∶3，活性炭用量是浓缩液体积的1.0%~1.5%，粗精粉重结晶得到纯品，含量97%。 |
| 关键词: 恩拉霉素 提取工艺 甲醇 |
| DOI： |
| 投稿时间：2021-02-19修订日期：2021-12-15 |
| 基金项目: |
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| Extraction Technology of Enramycin |
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| (Shandong Shengli Bioengineering Co, LTD) |
| Abstract: |
| To optimize extraction technology of Enramycin, 70% methanol solution was used to extract Enramycin, and then was concentrated, decolorized, crystallized, recrystallized. The active pharmaceutical ingredient (API) was produced. The optimized extraction technological conditions were pH 3.5~4.0, temperature 30℃, extraction time1h, three extraction process ed with material-liquid ratios 1∶7, 1∶3, 1∶3，1.0%~1.5% ratio of activated carbon / concentrated solution, recrystallized once. The product of Enramycin was 97%. |
| Key words: Enramycin extraction methanol solution |
