| 摘要: |
| 为了评价连翘颗粒剂的安全性，对其进行了昆明鼠的急性亚急性毒性试验。取昆明鼠80只随机分为四组：对照组，连翘各剂量组(100g/kg，33.3g/kg，10g/kg)。分别在给药的第7d和第14d时，对各组昆明鼠进行一般症状观察以及分别检测血液中的血红蛋白、红细胞数、白细胞数和血清中的谷草转氨酶（GOT）、谷丙转氨酶（GPT）、肌酐（CR）、尿素氮（BUN）和碱性磷酸酶（AKP）。结果表明，血液生理生化指标与正常组相比无显著差异。提示连翘颗粒剂的毒性较低，临床用药安全可靠。 |
| 关键词: 连翘颗粒剂 昆明鼠 急性毒性实验 亚急性毒性实验 |
| DOI： |
| 投稿时间：2012-10-31修订日期：2013-03-10 |
| 基金项目: |
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| Research of acute and subacute toxicity for Forsythiae granules |
| ,李艳华 |
| (Northeast Agricultural University,College of Veterinary Medicine,Harbin,China,150030) |
| Abstract: |
| In order to evaluate the security of Forsythiae granules, the acute and subacute toxicity of Forsythiae granules was tested in mice. 80 mice were randomly divided into four groups, control group, Forsythiae granules each does groups (100g/kg, 33.3g/kg, 10g/kg). At the 7th day and the 14th day of giving medicines, the common symptom of the mice was observed in each group. Then detection hemoglobin, erythrocytes number, leukocyte number and glutamic oxaloacetic transaminase (GOT)、glutamic-pyruvic transaminase (GPT)、creatinine (CR)、blood urea nitrogen (BUN)、alkaline phosphatase (AKP) in serum. The results showed that the blood physiological and biochemical indexes compared with the normal group were no significant differences. It also demonstrated that the Forsythiae granules had lower toxicity and were safety for clinical application. |
| Key words: Forsythiae granules mice acute toxicity test subacute toxicity test |
