| 摘要: |
| 含未甲基化CpG基序的寡脱氧核苷酸能够直接刺激B细胞等抗原递呈细胞，提高Th1产量并促进细胞因子的产生及抗原递呈细胞的成熟和活化。这使CpG 寡核苷酸具有良好的免疫佐剂活性，能够促进和提高抗原特异性免疫应答。本篇综述着重介绍了CpG寡核苷酸作为免疫佐剂的研究进展。 |
| 关键词: 佐剂 CpG 寡核苷酸 |
| DOI： |
| 投稿时间：2008-05-13修订日期：2008-07-07 |
| 基金项目: |
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| A New Immune Adjuvant—CpG Oligodeoxynucleotides |
| li na |
| (FuZhou DaBeiNong Biotechnology Ltd.Com) |
| Abstract: |
| Oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate B cells and other professional antigen-presenting cells, thereby promoting the production of Th1 and proinflammatory cytokines and the maturation or activation of professional antigen-presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen-specific immune responses. This review will highlight the recent uses of CpG DNA as an immune adjuvant. |
| Key words: Adjuvant CpG oligodeoxynucleotide |
