| 摘要: |
| 采用高效液相色谱法，对以80 mg/kg b.w.单剂量口灌磺胺甲噁唑的大菱鲆进行连续采样监测，研究大菱鲆口服磺胺甲噁唑的药代动力学特征及残留消除规律。结果表明，磺胺甲噁唑在大菱鲆血液、肌肉中药代动力学特征分别符合带时滞的一级吸收二室开放模型、一级吸收一室开放模型。磺胺甲噁唑在大菱鲆体内消除速度较慢，16℃水温的实验条件下，在大菱鲆肌肉中的休药期为27天。 |
| 关键词: 磺胺甲噁唑 大菱鲆 药代动力学 消除 高效液相色谱法 |
| DOI： |
| 投稿时间：2008-10-16修订日期：2008-10-16 |
| 基金项目: |
|
| Pharmacokinetics and Elimination of Sulfamethoxazole in Turbot |
| quzhina |
| (China Animal and Epidemiology Center) |
| Abstract: |
| The residue of SMZ in turbot which was exposured to 80 mg/kg b.w. SMZ solution was monitored continually by HPLC, and the pharmacokinetics and elimination of SMZ in turbot after oral administration were studied. The result showed that the concentration-time course of the drug conformed to the characteritics of the two compartment open model with the first order absorption and a lagtime for the blood, and the one compartment open model with first order absorption and a lagtime for the muscle. SMZ was slowly eliminated in turbot. The concerntration of SMZ in the muscle was below LOD after 27d。 |
| Key words: Qu zhina, Zhao Sijun, Wang Yudong,Lu Ping, Li Cunjin, Tan Weiquan, Sun Xiaoliang, Zheng Zengren |
