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邻羟基苯磺酰苯胺类抗肝片吸虫药物的解偶联活性研究
陈静
0
(内蒙古民族大学)
摘要:
本文通过采用氧电极技术研究药物浓度与线粒体呼吸控制率(RCR)关系。及测定线粒体呼吸过程中无机磷浓度的变化量两种方法,研究新合成的5个邻羟基苯磺酰苯胺类有机化合物的活性。结果表明,他们在较低浓度范围内有较强的解偶联活性。
关键词:  邻羟基苯磺酰苯胺 解偶联 杀虫活性
DOI:
投稿时间:2008-11-15修订日期:2009-01-10
基金项目:
The Study on the Uncoupling Activity of Some
chenjing
(inner mongolia university for the nationalities)
Abstract:
By the methods of measuring respiratory actlvities using a clark oxygen electrode and the change of inorganic phosphate in the respiratory process of mitochondri,these drugs , uncoupling action of the oxidative phosphorylation in mitochondria was studied . The results showed that these compounds all had uncoupling activity
Key words:  o-hydroxyl-benzenesulfonanilides Drug Uncoupling Activity fasciolicidal activity

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