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A型产气荚膜梭菌灭活疫苗类毒素含量与疫苗攻毒保护率之间的平行关系研究
白同臣
0
(哈药集团生物疫苗有限公司(原黑龙江省生物制品一厂))
摘要:
[摘 要] 本文测定了制苗菌液中外毒素对小白鼠最小致死量,并将该制苗菌液按《规程》[1]方法制成A型产气荚膜梭菌灭活疫苗,按《规程》方法进行安全和效力检验。结果表明: 3批疫苗安全检验全部合格;疫苗保护率与疫苗中类毒素含量呈正相关。
关键词:  A型产气荚膜梭菌  灭活疫苗;毒素;保护率;平行关系
DOI:
投稿时间:2008-12-12修订日期:2009-01-21
基金项目:
Study on the Paralleled Relationship between the anatoxine content of Clostridium perfringens type A and the Protection Rate of Toxic Substances
baitongchen
()
Abstract:
Abstract: In the experiment we detected MLD of ectotoxin of Clostridium perfringens type A to Mus musculus albus .Six batches inactivated vaccine of Clostridium perfringens type A are prepared with bacterium culture. The safe and effect test result shows that six batches vaccine are all safe to rabbits and the protection rate is correlated with anatoxine content of Clostridium perfringens type A...
Key words:  Clostridium perfringens type A  inactivated vaccine  toxin  protection rate  Parallelism Relation

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