| 摘要: |
| 通过对肺靶向氟苯尼考明胶微球进行溶血实验、刺激实验及急性毒性试验，考察其对受试动物的血液相容性及毒性，评价肺靶向氟苯尼考明胶微球作为静脉注射药物的可行性和安全性。实验结果显示，不同剂量的肺靶向氟苯尼考明胶微球注射剂的溶血指数均小于5%，无明显毒性；10%氟苯尼考明胶微球注射剂对受试动物皮肤无明显刺激作用；肺靶向氟苯尼考明胶微球对小鼠的LD50为2.226 7 g/kg，LD50 95%的可信限为1.950 2 ~2.635 6 g/kg。说明肺靶向氟苯尼考明胶微球毒副作用小，符合注射剂的相关要求，具有良好的临床应用前景。 |
| 关键词: 氟苯尼考 明胶微球 血液相容性 毒理学 |
| DOI： |
| 投稿时间：2009-07-16修订日期：2009-10-27 |
| 基金项目: |
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| Studies on Blood Compatibility and Toxicology of Lung Targeting Gelatin Microspheres of Florfenicol |
| liulan |
| (Dabeinong Animal Health Technology Research Center) |
| Abstract: |
| Through the evaluation tests of lung targeting gelatin microspheres of florfenicol including hemolysis, stimulation and systemic acute toxic tests to study the blood compatibility and toxicological characteristics, and to evaluate the feasibility and safety as the role of intravenous drugs. The results showed that under different doses the hemolytic index of the gelatin microspheres was lower than 5%, so it did not have significant toxicity; primary skin irritation test showed there were no erythema, eschar and edema of 10% florfenicol gelatin microspheres injection; the LD50 of the microspheres was 2.226 7 g/kg and its 95% credibility limit was 1.950 2~2.635 6 g/kg. The lung targeting gelatin microspheres of florfenicol have few toxicity, in line with the requirements of injection, and have good clinical application prospects. |
| Key words: florfenicol gelatin microspheres blood compatibility toxicology |
