| 摘要: |
| 采用新药乳酸恩诺沙星测定了其对实验小鼠的半数致死量（LD50）, 为其可溶性粉开展药效试验提供依据。按照农业部关于一般毒性试验及临床试验规范进行试验。结果表明, 乳酸恩诺沙星对小白鼠灌胃染毒及腹腔注射染毒的 LD50分别为3579 mg/kg,和571.3 mg/kg，其95％可信限分别为3011~4255 mg/kg和498.3~655.1 mg/kg。研究提示, 乳酸恩诺沙星属低毒物质，其可溶性粉能用于开展药效试验。 |
| 关键词: 乳酸恩诺沙星 小鼠 急性毒性 |
| DOI： |
| 投稿时间：2009-12-28修订日期：2010-02-08 |
| 基金项目:国家蛋鸡产业技术体系项目 (NYCYFX-g09) |
|
| Acute toxicity of enrofloxacin lactate in mice |
| Tang Yiming |
| (College of Animal Sciences Zhejiang University) |
| Abstract: |
| The acute toxicity test in mice was studied. LD50 values and its 95% confidence limits were calculated according to Karber method. The results showed that the LD50 of enrofloxacin lactate in mice ig and ip was 3579 and 571.3 mg/kg.bw, its 95% confidence limits were between 3011 mg/kg and 4255 mg/kg, 498.3 mg/kg and 655.1 mg/kg, respectively. We conclude that enrofloxacin lactate is a safe antibacterial agent with low toxicity, and it can be used in the following efficacy test. |
| Key words: enrofloxacin lactate mice acute toxicity |
