| 摘要: |
| 三组猪（n=5）分别按2.5mg/kg的剂量肌肉注射拜有利5%、恩诺沙星注射液A、恩诺沙星注射液B三种药物，HPLC法测定血药浓度，winnonlin6.1拟合血药浓度—时间数据，计算参数。三种注射液均符合一室开放模型，峰浓度分别为：0.87μg/mL、0.63μg/mL、0.49μg/mL，AUC分别为6.32 h•μg•mL-1、5.31 h•μg•mL-1、3.45 h•μg•mL-1。实验结果表明：拜有利5%在猪体内的药代动力学参数优于注射液B，注射液B的优于注射液A，结果提示恩诺沙星注射液B与拜有利5%相比临床防治效果略差，药物吸收可做进一步改进。 |
| 关键词: 恩诺沙星 药代动力学 HPLC |
| DOI： |
| 投稿时间：2010-01-11修订日期：2010-02-24 |
| 基金项目: |
|
| Pharmacokinetics of Three Enrofloxacin Injections in Swine |
| zhang xiao-hui |
| (Luoyang Huizhong Animal Medicine co., ltd) |
| Abstract: |
| Three groups of swine(n=5) were injected intramuscularly Baytril 5%, enrofloxacin injectionA, and enrofloxacin iniejction B. Plasma concentration was measured by HPLC, and concentration-time data was processed by winnonlin6.1. The results showed that models of all groups were best fit by one-compartment open model with peak concentration of 0.87μg/mL, 0.63μg/mL,0.49μg/mL, and AUC of 6.32 h•μg•mL-1, 5.31 h•μg•mL-1, 3.45 h•μg•mL-1. Baytil 5% is the best in pharmacokinetics, then injection B, injection A last. It indicated that injection B was improved significantly, is slightly inferior to Baytril 5%. Its pharmacokinetic attribute of absorption should be improved. |
| Key words: enrofloxacin, pharmacokinetics, HPLC |
