| 摘要: |
| 摘要：以盐酸阿苯达唑亚砜原料为基础，通过反复提纯，得到盐酸阿苯达唑亚砜对照品候选物，该候选物经过熔点，TLC薄层色谱法和高效液相色谱法检测，初步确认符合对照品的要求，经过高效液相色谱检测，采用面积归一化法计算其纯度不小于99.5%。该方法的建立为盐酸阿苯达唑对照品进一步研究提供了帮助。 |
| 关键词: 阿苯达唑亚砜盐酸盐 TLC薄层检测 高效液相检测 面积归一化 |
| DOI： |
| 投稿时间：2010-04-12修订日期：2010-05-18 |
| 基金项目:国家科技支撑计划（2006BAD31B04）经济型新化学合成药的研制与应用 |
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| Establishment for detecting purity of Albendazole Sulfoxide Hydrochloride Reference Substance candidates |
| liuzhiliang |
| () |
| Abstract: |
| Abstract: Albendazole sulfoxide hydrochloride candidate was obtained through repeatedly purify the base material- Albendazole sulfoxide hydrochloride raw material. This control article was initially confirmed to the standard comply by detection of Melting Point, Thin-Layer Chromatography (TLC) and High Performance Liquid Chromatography (HPLC). Through detection of HPLC method and calculation of area normalization method, the content of this control article not less than 99.5%. The method provided help for further study of Albendazole Sulfoxide Hydrochloride Reference Substance. |
| Key words: Albendazole sulfoxide hydrochloride, Thin-Layer Chromatography (TLC), High Performance Liquid Chromatography (HPLC), Area normalization method |
