| 摘要: |
| 摘要：马立克氏病病毒（MDV）的致病性一直在不断增强中，甚至已出现了能抵抗CV1988/Rispens疫苗的特超强株。为此，科学家一直在研究更有效的新疫苗。已有报道表明，用感染性克隆技术构建的肿瘤Meg基因缺失株，不仅没有致肿瘤性而且能提供比CV1988/Rispens株疫苗更好的保护性免疫。本实验室也用BAC克隆技术构建了MDV中国野毒株的Meg基因缺失株，显示出在抗马立克氏病方面具有与美国Meg基因缺失株同样有效的保护性免疫效果，而且其自身没有明显的免疫抑制作用。本文对美国和中国的二个MDV的Meg基因缺失株的优缺点做了比较。 |
| 关键词: 马立克氏病病毒，Meg基因缺失株， 保护性免疫 |
| DOI： |
| 投稿时间：2010-08-27修订日期：2010-08-27 |
| 基金项目:国家自然科学基金项目（面上项目） |
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| Comparison of two Marek’s disease virus Meq-deletion mutants |
| cuizhizhong |
| (College of Veterinary Medicine, Shandong Agricultural University) |
| Abstract: |
| Abstract: The pathogenicity of Marek’s disease viruses (MDV) is being continuously increased, even some very virulent plus MDV strains resistant to CVI988/Rispens emerged. Scientist has to continue their researches on new vaccines for better protective efficacy against MDV. It was reported that a Meq-deletion mutant of Md5 provided better protective immunity against vvMDV and VV MDV than CVI988/Rispens. Our lab also constructed a Meq-deletion mutant from Chinese field strain GX0101 with BAC clone technique, it also demonstrated better protective immunity than CVI988. In this paper, both Meq-deletion mutants were compared for their protective immunity and other biological characteristics. |
| Key words: Marek’s disease viruses, Meq-deletion mutants, protective immunity |
