| 摘要: |
| 利用反向遗传操作系统拯救出狂犬病毒的携带双G基因的HEP-dG株,选用新型佐剂制成狂犬病灭活疫苗，进行小鼠免疫试验、比格犬最小免疫剂量试验、免疫持续期试验。试验表明，携带双G基因的HEP-dG株具有良好的免疫原性，该新型佐剂狂犬病灭活疫苗免疫效果较好，具有完全的保护力和较长的免疫保护持续期。 |
| 关键词: 狂犬病灭活疫苗 佐剂 免疫试验 |
| DOI： |
| 投稿时间：2010-10-14修订日期：2010-10-14 |
| 基金项目: |
|
| Development of Rabies Inactivated Vaccine with a New Type Adjuvant |
| zhu mingwen |
| (1) |
| Abstract: |
| Recombinant HEP-dG Rabies virus stock was rescued by the technique of reverse genetics，inactivated rabies vaccines with a new trpe adjuvant for immune test were conducted in mice and the minimum immune dose test were conducted in Beagle. The results demonstrated that recombinant HEP-dG Rabies virus strain has good immunogenicity，and the Rabies inactivated vaccines were effective and protective. |
| Key words: Rabies inactivated vaccines adjuvant immune test |
