| 摘要: |
| 对硫代呋喃甲酸进行精制,用乙酸乙酯作溶剂,与7-ACA反应得到头孢呋酸(收率95.6%,含量≥98.0% (HPLC归一化法)),在三乙胺作用下直接与AE-活性酯缩合得到头孢噻呋(收率：74.2%,含量≥95.0% (HPLC外标法)),产品可直接制备冻干粉。 |
| 关键词: 头孢呋酸 精制 缩合 头孢噻呋 |
| DOI： |
| 投稿时间：2011-07-07修订日期：2011-08-03 |
| 基金项目: |
|
| Modification of Synthetic Method of Ceftiofur |
| Zhao zengren |
| (guojiashouyaogongchengjishuyanjiuzhongxin) |
| Abstract: |
| Purified 3-Thiofuroyi-formic acid reacts with 7- ACA to get 3-Thiofuroyi
-7-Aminocephalosporanic acid using ethyl acetate as solvent (yield :95.6% , ), highly pure product(≥ 98.0％,HPLC)．under the action of triethylamine, 3-Thiofuroyi-7-
Aminocephalosporanic acid reacts with AE-thiolester to get ceftiofur (yield: 74.2%), highly pure product(≥ 95.0％,HPLC) , which can be prepared for freeze-dried powder directly . |
| Key words: 3-thiofuroyi-7-aminocephalosporanic acid purification 7-ACA ceftiofur |
