| 摘要: |
| 研究头孢噻呋钠在成年麻鸭体内的药动学特征及生物利用度,为临床制定合理的给药方案提供科学依据。选取24只健康的成年麻鸭(体重1.6?0.2kg),随机分为3组,以2mg.kg-1剂量分别单次肌内注射、静脉注射和内服头孢噻呋钠,采用HPLC法检测血药浓度,计算头孢噻呋的药动力学参数和肌注、内服的生物利用度。结果表明：静脉注射头孢噻呋钠后,血药浓度经时数据符合二室开放模型,主要动力学参数：t1/2α为0.19?0.22h,t1/2β为3.64?0.22h,Vd为0.48?0.06L.kg-1,CL为0.07?0.01 L.kg-1.h-1,AUC为27.09?2.84μg.mL-1.h-1；肌内注射后,血药浓度经时数据符合二室开放模型,主要动力学参数：t1/2α为0.38?0.02h,t1/2β为4.56?0.29h,Tmax为0.49?0.17h,Cmax为6.44?0.44μg.mL-1,AUC为26.88?0.48μg.mL-1.h-1,生物利用度为99.22%；内服后,血药浓度经时数据符合二室开放模型,主要动力学参数：t1/2α为0.77?0.14h,t1/2β为3.81?0.23h,Tmax为1.06?0.23h,Cmax为3.62?0.20μg.mL-1,AUC为21.47?0.44μg.mL-1.h-1,生物利用度为79.25%。头孢噻呋钠在成年麻鸭体内吸收迅速,半衰期较长,肌注的生物利用度高,内服吸收良好。 |
| 关键词: 头孢噻呋钠 麻鸭 药代动力学 生物利用度 |
| DOI： |
| 投稿时间：2012-05-16修订日期：2012-05-28 |
| 基金项目: |
|
| Studies on Pharmacokinetics of Ceftiofur Sodium in Brown Ducks |
|
| (College of Animal Science and Nutrition Engineering,Wuhan Polytechnic University) |
| Abstract: |
| Pharmacokinetics and bioavailability of ceftiofur sodium in adult brown ducks were studied to provide a scientific basis for a reasonable clinical program.24 healthy adult brown ducks(1.6?0.2kg) which had been divided into three group were respectively administrated of ceftiofur sodium (2mg.kg-1) by intramuscular injection, intravenous injection and oral gavages. The drug concentrations in plasma of ducks in each group were detected with high-performance liquid chromatogram (HPLC), and the pharmacokinetic parameters and the bioavailability were analyzed with Drug and Statistics (DAS). The results showed that the drug concentration-time data of ceftiofur following intravenous injection administration was well described by a two -compartment open model. The main parameters were as follow: t1/2α 0.19?0.22h, t1/2β 3.64?0.22h, Vd 0.48?0.06L.kg-1, CL 0.07?0.01 L.kg-1.h-1, AUC 27.09?2.84 μg.mL-1.h-1. The drug concentration-time data of ceftiofur following intramuscular injection administration was well described by a two-compartment open model. The parameters were as follow: t1/2α 0.38?0.02h,t1/2β 4.56?0.29h, Tmax 0.49?0.17h, Cmax 6.44?0.44μg.mL-1, AUC 26.88?0.48μg.mL-1.h-1 and the bioavailability 99.22%; The drug concentration-time data of ceftiofur following oral administration was well described by a two-compartment open model. The main parameters were as follow: t1/2α 0.77?0.14h, t1/2β 3.81?0.23h, Tmax 1.06?0.23h, Cmax 3.62?0.20μg.mL-1, AUC 21.47?0.44μg.mL-1.h-1 and the bioavailability 79.25%. These results showed that ceftiofur was rapidly absorbed and had a long half-time in brown ducks. Ceftiofur had a high rate of bioavailability by intramuscular injection and was well absorbed by oral administration. |
| Key words: ceftiofur sodium brown duck pharmacokinetics bioavailability |
