| 摘要: |
| 综述了模式识别受体（Pattern recognition receptors,PRRs）及其相关分子佐剂的研究进展。PRRs是一类表达于固有免疫细胞并可识别病原体相关分子模式的识别分子。PRRs主要包括Toll样受体、NOD样受体、RIG-Ⅰ样受体、清道夫受体、甘露糖受体和髓系细胞触发受体等。与PRRs直接相关的分子佐剂主要包括TLR激动剂、NLR激动剂、RIG-Ⅰ和MDA5激动剂及CD40和肿瘤坏死因子受体超家族（TNFRSF）激动剂等。 |
| 关键词: 模式识别受体 分子佐剂；激动剂 |
| DOI： |
| 投稿时间：2012-06-25修订日期：2012-07-30 |
| 基金项目:农业部2012年引进国际先进农业科学技术计划（948计划）项目——“兽药监管技术引进”（2012-G14）；农业部农产品质量安全监管专项——“兽药及兽药残留检测标准物质研制与制备”（2130109）。 |
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| Progress of Pattern Recognition Receptors and Its Relevant Molecular Adjuvants |
|
| (China Institute of Veterinary Drug Control) |
| Abstract: |
| In this paper, the developments of PRRs and its relevant molecular adjuvants were reviewed.PRRs were a kind of recognition molecules expressed on innate immune cells that can recognize pathogen-associated molecular patterns (PAMPs). PRRs mainly included Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-Ⅰ like receptors (RLRs), scavenger receptors (SRs), mannose receptors (MRs) and triggering receptors expressed on myeloid cells (TREMs), etc. Molecular adjuvants directly related to PRRs mainly including TLR agonists, NLR agonists, RIG-I |
| Key words: pattern-recognition receptors (PRRs) molecular adjuvants agonist |
