| 摘要: |
| 为研究了自制的盐酸多西环素注射液在健康猪的药效-药代动力学。，对10头健康猪单次肌肉注射肌内注射盐酸多西环素注射液后，采用UPLC法测定血浆中药物浓度，利用药代动力学软件WinNonlin进行数据处理。结果显示，主要药代动力学参数：消除相半衰期HL_Lambda_z为(（31.3±9.2)） h，达峰时间T max为（(0.80±0.7)） h ，峰浓度Cmax为（(4132±2475)） μg/L，药时曲线下面积AUC为(（88378±88095)） (μg/L)?h，平均滞留时间MRT为(（20.5±2.5)） h。PK/PD参数T>MIC为24 h，AUC/MIC>50，表明该制剂以10 mg?/kg-1 剂量肌肉注射肌内注射，给药间隔为两天一次。 |
| 关键词: 多西环素 药代动力学 药效学 猪 UPLC |
| DOI： |
| 投稿时间：2014-04-15修订日期：2014-05-06 |
| 基金项目: |
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| Pharmacokinetics of Doxycycline Hydrochloride Injection in Swine after Intramuscular Injection |
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| (China Institute of Veterinary Drug Control) |
| Abstract: |
| Pharmacokinetics and pharmacodynamicsof a single dose of self-made doxycycline hydrochloride injection in healthy swines was studied. 10 healthy swines received 10 mg?/kg-1 of doxycycline hydrochloride intramuscularly. The concentrations of drug in plasma were determined by UPLC and the pharmacokinetics parameters were calculated by WinNonliln software. The main pharmacokinetics parameters were as follow: HL_Lambda_zelimination half lifewere was (31.3±9.2) h, Tmax, Cmax, AUC, MRT were (0.80±0.7) h, (4132±2475) μg/L, (88378±88095) (μg/L)?hand (20.5±2.5) h, respectively. And PK/PD parameter of T>MIC was 24 h and AUC/MIC>50. The doxycycline hydrochloride injectionintramuscularly given to swineby 10 mg?/kg-1 and the dosing inteval withonce per two days was recommended. |
| Key words: doxycycline pharmacokinetics pharmacokinetics swine UPLC |
