| 摘要: |
| 预测了兽用盐酸多西环素注射液稳定pH值。在广泛pH范围内，采用经典恒温法和单测点法对所研制的盐酸多西环素注射液进行化学稳定性研究，探讨pH值与稳定性之间的关系。结果表明，这两种方法预测的稳定pH值及稳定pH值范围基本一致，盐酸多西环素注射液最稳定pH值［(pH)m］为4.0，与经典法比较，单侧点法工作量小，简单易行。 |
| 关键词: 盐酸多西环素 注射液 稳定性 pH值 经典法 单侧点法 |
| DOI： |
| 投稿时间：2014-05-29修订日期：2014-07-07 |
| 基金项目: |
|
| A Study of the Stable pH Value of Doxycycline Hydrochloride Injection |
|
| (China Institute of Veterinary Drug Control) |
| Abstract: |
| The stable pH value of the veterinary doxycycline hydrochloride injection was predicted. The chemical stability of doxycycline hydrochloride injection was studied in the extensive pH range by classical isothermal kinetic method and single point kinetic method. The relationship between stability and pH value of the injection was investigated. The results showed that, the most stable pH value and stable pH range that predicted by the two methods were basically identical. The most stable pH value of doxycycline hydrochloride injection was 4.0. Single point kinetic method was simple and its workload was small compared with the classical kinetic method. |
| Key words: doxycycline hydrochloride injection stability pH value classical isothermal kinetic method single point kinetic method |
