| 摘要: |
| 为了评价沙咪珠利的安全性，对其进行了小鼠精子畸形和骨髓细胞微核试验研究。选择健康ICR小鼠随机分为受试物高、中、低剂量组，阳性对照组和阴性对照组，进行精子畸形试验和骨髓细胞微核试验，计算精子畸形率和微核率。结果显示受试物各剂量组精子畸形率与骨髓细胞微核率与阴性对照组比较差异不显著（P＞0.05），与阳性对照组比较，差异有统计学意义（P＜0.01）。表明沙咪珠利对小鼠精子和骨髓细胞微核无影响，不具有遗传毒性。 |
| 关键词: 沙咪珠利 精子畸形 骨髓细胞微核 |
| DOI： |
| 投稿时间：2016-02-24修订日期：2016-03-08 |
| 基金项目:] 本课题获江苏高校优势学科建设工程资助项目(PAPD)资助。[ |
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| Effects of Ethanamizuril on sperm deformity and bone marrow cell micronucleus of mice |
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| (Veterinary Medicine College,Yangzhou University) |
| Abstract: |
| In order to evaluate the security of Ethanamizuril, the sperm deformity and bone marrow cell micronucleus of Ethanamizuril. Healthy ICR mice were randomly divided into sample high group, sample medium group, sample low group, positive control group and negative control group, made sperm abnormality test and bone marrow micronucleus test, then calculated the sperm deformity rate and micronucleus rate. The results showed Ethanamizuril in each group was no statistical differences compared with negative control group (P>0.05). When compared with positive control group, the differences was statistically significant (P<0.01). Indicated Ethanamizuril has no effect on sperm deformity and bone marrow cell micronucleus of mice, it has no genetic reproductive toxic to mice. |
| Key words: Ethanamezuril Sperm deformity Bone marrow cell micronucleus |
