| 摘要: |
| 喹噁啉类药物的肾上腺毒性作用主要表现为对醛固酮合成和分泌的影响。随着喹噁啉类药物作为抗菌促生长剂在畜牧业中的广泛应用，其肾上腺毒性逐渐受到关注。本文从醛固酮合成过程和肾素-血管紧张素-醛固酮系统这两方面，综述了近年来该类药物对醛固酮影响的研究进展，旨在为后期进一步揭示喹噁啉类药物的肾上腺毒性做出贡献。 |
| 关键词: 喹噁啉 醛固酮 毒性 肾上腺 喹烯酮 乙酰甲喹 |
| DOI： |
| 投稿时间：2016-03-11修订日期：2016-05-04 |
| 基金项目:国家自然科学基金项目(31272614)；国家重点基础研究发展计划("973")项目(2009CB118800) |
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| Research Progress on the Inhibition of Quinoxaline Drugs on Synthesis and Secretion of Aldosterone |
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| (National Reference Laboratory of Veterinary Drug Residues HZAU,Key Laboratory of the Detection for Veterinary Drug Residues,Ministry of Agriculture,PR China,Huazhong Agricultural University,Wuhan,Hubei) |
| Abstract: |
| The adrenal toxicity of quinoxalines is mainly reflected by the effects on aldosterone. With the widespread use of quinoxalines as antimicrobials and growth promoters for animals, adrenal toxicity of these drugs is becoming a matter of urgent concern. In terms of the synthesis of aldosterone and Renin-Angiotesin-Aldosterone system, this paper reviews the progress on metabolism change of aldosterone affected by quinoxalines. We hope the review can make some contributions to further elucidation the adrenal toxicity induced by quinoxalines. |
| Key words: quinoxaline aldosterone toxicity adrenal quinocetone mequindox |
