| 摘要: |
| 建立了一种仪器分析技术确证氟甲喹化学结构的方法。采用紫外光谱（UV）、红外光谱（IR）、质谱、一维（1H、13C、DEPT）和二维（HSQC、HMBC、1H–1H COSY）核磁共振谱、热重分析（TGA）、差示扫描量热法（DSC）以及X—射线粉末衍射（PXRD）对氟甲喹进行结构分析。讨论了紫外和红外吸收特征峰，详细归属了所有的1H-NMR和13C-NMR信号，并对热分析（TGA/DSC）结果进行了解析，确定了与晶型相关的不同衍射角的特征衍射峰。以上研究结果确证了氟甲喹的化学结构。 |
| 关键词: 氟甲喹 波谱学 波谱特征 结构确证 |
| DOI： |
| 投稿时间：2016-03-16修订日期：2016-05-03 |
| 基金项目:上海市技术性贸易措施应对专项项目（14TBT007；15TBT009） |
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| Spectral Analysis and Structural Confirmation of Flumequine |
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| (Shanghai Institute of Measurement and Testing Technology) |
| Abstract: |
| A method for determination of chemical structure of flumequine was established. The structure was elucidated by UV, IR, MS, 1D NMR (1H, 13C, DEPT) and 2D NMR (HSQC, HMBC, 1H–1H COSY), DSC, TGA, and PXRD. The UV and IR absorption peaks were discussed, and all the signals of 1H-NMR and 13C NMR were attributed to their respective structures and positions in the molecule. The test result of TGA /DSC was analyzed，and the diffraction peaks of the different diffraction angles related to the crystal form were determined．The experiment verified that the chemical structure of this compound is flumequine. |
| Key words: flumequine spectroscopy spectroscopic characteristic structure confirmation |
