| 摘要: |
| 肉毒中毒症是一种急性、高度致死性、中毒性疾病，接种疫苗是预防该病最有效的方法之一。用于预防肉毒中毒症的传统疫苗有灭活菌苗和类毒素疫苗，近年来对于重组亚单位疫苗、重组嵌合体疫苗和DNA疫苗等得研究成为热点，本文着重对这些新型疫苗的发展现状进行了综述，以期为相关研究提供借鉴。 |
| 关键词: 肉毒中毒症 毒素 疫苗 |
| DOI： |
| 投稿时间：2016-06-03修订日期：2016-08-28 |
| 基金项目: |
|
| Current Status of Research on Botulism Vaccines |
|
| (China Institute of Veterinary Drug Control) |
| Abstract: |
| Vaccination was one of the most effective ways to prevent botulism which is an acute, highly fatal and toxic disease. The traditional vaccines included inactivated vaccines and toxoid vaccines, and the new types of vaccines included recombinant subunit vaccines, recombinant chimeric vaccines and DNA vaccines. This paper reviews about the current status of research on these vaccines which had been developed rapidly in recent years in order to provide reference for development on botulism vaccines. |
| Key words: botulism neurotoxin vaccine |
