| 摘要: |
| 抗菌增效剂是一类广谱、高效、低毒的药物,广泛应用于临床.本文对二氨基嘧啶类抗菌增效剂进行详细的毒性作用综述,主要包括急性毒性、长期毒性、遗传毒性等,为评价其安全性,指导临床合理使用,开发新药,避免其应用危害提供参考。 |
| 关键词: 甲氧苄啶 二甲氧苄啶 巴喹普林 奥美普林 艾地普林 毒性 |
| DOI： |
| 投稿时间：2018-08-24修订日期：2019-01-09 |
| 基金项目: |
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| ((National Reference Laboratory of Veterinary Drug Residues (HZAU), MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, 430070, China)) |
| Abstract: |
| Diaminopyrimidine antibacterial synergist is a kind of high-efficiency, low-toxic drug, widely used in clinical practice.. This paper reviews the toxicity of diaminopyrimidine antimicrobial synergists, mainly including acute toxicity, long-term toxicity and genetic toxicity, in order to provide a reference for evaluating their safety, guiding clinical rational use, developing new drugs and avoiding the harm of their application. |
| Key words: Trimethoprim Diaveridine Baquiloprim Ormetoprim Aditoprim Toxicology |
