| 摘要: |
| 本试验旨在研究临床使用常规剂量及养殖环节加大剂量盐酸土霉素可溶性粉后，其在鸡蛋中的残留消除规律。对产蛋期蛋鸡分别给予500 mg/L和667 mg/L 50%盐酸土霉素可溶性粉，集中饮水给药，每日1次，连续5 d。分别采集停药后1 d到12 d的鸡蛋样品，采用UPLC-MS/MS测定鸡蛋中土霉素的残留量。按上述方法给药后，低、高剂量组分别在停药第1 d和停药第2 d达到土霉素残留量最高。低、高剂量组的最高残留量分别为142.72 μg/kg、82.84 μg/kg，均低于国家规定的最高残留限量（200 μg/kg），不会造成土霉素残留超标。本试验通过研究霉素可溶性粉在鸡蛋中的残留情况，确定弃蛋期前后土霉素残留量，以期为蛋鸡产蛋期安全用药，保障食品安全提供科学依据。 |
| 关键词: 盐酸土霉素 残留消除 鸡蛋 |
| DOI： |
| 投稿时间：2019-06-17修订日期：2019-08-15 |
| 基金项目: |
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| Study on the Degradation of Oxytetracycline in Chicken Eggs |
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| (Henan Institute of Veterinary Drug and Feed Control) |
| Abstract: |
| This study aimed to study the degradation of the residues in eggs after clinical use of oxytetracycline hydrochloride soluble powder. Two groups of layers took 50% oxytetracycline hydrochloride soluble powder of 500 mg/L and 667 mg/L concentrations respectively at water-drinking times for 5 days consecutively, one time per day. Eggs were collected on day 1 through day 12 after the withdrawal of the drug, and the residues were tested by UPLC-MS/MS method. The study showed that the peak level of drug residual for the lower dose group and higher dose group were reached on day 1 and day 2 after drug withdrawal; and the maximum amount of residue in the lower lose group and higher dose group were 142.72 μg/kg and 82.84μg/kg respectively, both of them were lower than the maximum residue limit (200 μg/kg) in the State provisions, the level of the oxytetracycline residue did not exceed the standard. By studying the residue of oxytetracycline hydrochloride soluble powder in eggs, this experiment determined the residual amount of oxytetracycline before and after egg abandoning period, so as to provide scientific basis for the safe use of drugs in laying period and ensuring food safety. |
| Key words: Oxytetracycline hydrochloride Degradation of Residue eggs |
