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一测多评法同时测定麻杏石甘口服液中3种成分含量
黄松,崔明旭,刘爱玲,栗栖凤,史德胜,孙月川,王一凡,刘桂兰,李守军
0
(天津渤海农牧产业联合研究院有限公司;瑞普天津生物药业有限公司)
摘要:
[目的]建立麻杏石甘口服液中盐酸麻黄碱、盐酸伪麻黄碱和苦杏仁苷3种成分含量的一测多评方法。[方法]以盐酸麻黄碱为内参物,建立盐酸伪麻黄碱和苦杏仁苷与盐酸麻黄碱的相对校正因子,分别采用外标法与一测多评法测定3种成分的含量,比较两种方法测得结果的差异,验证一测多评方法的可行性。[结果]盐酸麻黄碱与盐酸伪麻黄碱、苦杏仁苷的相对校正因子分别为1.233和2.741,一测多评法与外标法测定结果无显著性差异,相对误差小于0.3 %。[结论]一测多评法运用于麻杏石甘口服液的含量测定准确可行。
关键词:  一测多评法  高效液相色谱法  麻杏石甘口服液  盐酸麻黄碱  盐酸伪麻黄碱  苦杏仁苷
DOI:
投稿时间:2019-06-18修订日期:2019-09-18
基金项目:
Simultaneous determination of 3 constituents in Maxing Shigan oral medicinal liquid by HPLC-QAMSHUANG Song,CUI Mingxu, Liu Ailing,Li Qifeng,SHI Desheng,SUN Yuechuan,WANG Yifan,LIU Guilan,Li Shoujun
(Tianjin Bohai Agricuilture-Animal Husbandry Union)
Abstract:
[Objective]To establish a method of quantitative analysis of multi-components by single marker (QAMS) for the determination and evaluation of three constituents (ephedrine hydrochloride, pseudoephedrine hydrochloride and amygdalin )in Maxing Shigan Oral Medicinal Liquid.[Methods]Ephedrine hydrochloride was used as internal reference substance, and the relative correction factors(RCF) of pseudoephedrine hydrochloride and amygdalin to ephedrine hydrochloride were calculated and evaluated. The content of the three components were determined by the external standard method(ESM) and QAMS, respectively. The difference between the two methods was compared to verify the feasibility of the method.[Resμlts]the RCF of pseudoephedrine hydrochloride and amygdalin to ephedrine hydrochloride were 1.233 and 2.741, respectively. There was no significant differences between the results of external standard method and QAMS, and the relative error was less than 0.3%.[Conclusion]the QAMS method is feasible and accurate for the simultaneoμs determination of Maxing Shigan Oral Medicinal Liquid.
Key words:  QAMS  HPLC  Maxing Shigan Oral Medicinal Liquid  Ephedrine hydrochloride  Pseudoephedrine hydrochloride  Amygdalin

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