| 摘要: |
| 概述了马波沙星的理化性质、合成途径、作用机制与体外抗菌活性、安全性以及含量或残留检测方法。马波沙星是动物专用的新型氟喹诺酮类抗菌药，主要通过抑制细菌拓扑异构酶的活性而发挥作用，具有抗菌谱广、安全高效、交叉耐药少等特点，在防治动物疾病领域具有广阔的应用前景。 |
| 关键词: 马波沙星 合成途径 体外抗菌活性 安全性 检测方法 |
| DOI： |
| 投稿时间：2020-04-21修订日期：2021-01-12 |
| 基金项目: |
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| Research Progress of Marbofloxacin |
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| (China Institute of Veterinary Drug Control) |
| Abstract: |
| In this paper, the research progress about physico-chemical properties, synthesis pathway, mechanism, in vitro antibacterial activity, safety and detection methods of marbofloxacin were reviewed．As a new type of fluoroquinolone antibacterial drug, marbofloxacin, with many advantages such as broad antimicrobial spectrum, strong and fast antimicrobial effects, a few adverse reactions and non-cross-resistant, acts mainly by inhibition of bacterial DNA-gyrase, which has a broad application prospect in the field of animal disease prevention and control. |
| Key words: marbofloxacin synthesis pathway in vitro antibacterial activity safety detection methods |
