| 摘要: |
| 为了制备穿心莲内酯纳米混悬剂(ANDRO-NS),试验采用反溶剂法制备ANDRO-NS,正交试验筛选优化ANDRO-NS的制备工艺。结果显示在处方和工艺筛选的基础上,确定最优处方,选择吐温-80为1%、泊洛沙姆为0.05%为稳定剂,药物浓度为40mg/mL,反溶剂和溶剂的体积比为20,搅拌速率为1400 r/min,搅拌时间为80min,制得的ANDRO-NS平均粒径为(568.51±13.74)nm,粒径合适,稳定性良好。表明反溶剂沉淀法制备的ANDRO-NS工艺简单,值得进一步研究 |
| 关键词: 穿心莲内酯 纳米混悬剂 反溶剂沉淀法 正交试验 反溶剂法 |
| DOI： |
| 投稿时间：2020-08-21修订日期：2020-12-30 |
| 基金项目:河南省高等学校重点科研项目(17A230006)； |
|
| Preparation of Andrographolide Nanosuspensions by anti-solvent method |
|
| (College of Animal Husbandry and medical engineering, Xinyang Agriculture And Forestry University,) |
| Abstract: |
| To prepare andrographolide nanosuspension(ANDRO-NS),the anti-solvent precipitation method was used,and the formulation was optimized by orthogonal test. The results were that,base on the screened formulation and technological parameters ,the optimal formulation was：Tween80 and F68 were used as stabilizer and co-stabilizer respectively. The ratio of Tween80 to F68 was 20:1,and the ratio of good solvent to poor solvent was 1:20. The concentration of the drug was 40mg/mL and 1400r/min of stirring speed,80 minute of stirring time The average particle size of ANDRO-NS was 568.51±13.74 nm,The particle size is suitable and stability. In conclusion the ANDRO-NS prepared using the anti-solvent precipitation method was simple and easy and was worthy of further study. |
| Key words: Andrographolide nanosuspensions anti-solvent precipitation method Orthogonal test Antisolvent method. |
