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UPLC-PDA联合UPLC-MS/MS法确证一批未知药品中的卡那霉素
魏秀丽,张传津,张琦,刘霄飞,张志民,杨志昆
0
(山东省兽药质量检验所)
摘要:
采用UPLC-PDA联合UPLC-MS/MS方法确证了未知药品中的卡那霉素。样品经提取稀释后,采用ACQUITY UPLC T3色谱柱为分离柱,UPLC-PDA初步筛查,再用正离子扫描,液相色谱串联质谱仪上机测定。结果显示,未知物确证是卡那霉素;样品检出限为0.1 μg/mL,定量限为0.2 μg/mL。本方法快速、灵敏、重现性好,适用于此批次未知药品中卡那霉素的检测。
关键词:  卡那霉素  未知药品  超高效液相-串联质谱法
DOI:
投稿时间:2021-01-08修订日期:2021-05-28
基金项目:2015年国家科技支撑计划“兽药安全与质量评价技术研究与应用”(BAD11B03-01)
UPLC-PDA combined UPLC-MS/MS method to confirm kanamycin in a batch of unknown drugs
(Shandong Provincial Veterinary Medicine Supervision Institute,Jinan)
Abstract:
UPLC-PDA combined UPLC-MS/MS method was used to confirm kanamycin in unknown drugs. The sample was extracted and diluted, and the ACQUITY UPLC T3 chromatographic column was used as the separation column, UPLC-PDA preliminary screening, then positive ion scanning, liquid chromatography series mass spectrometer on the machine. The results showed that the unknown substance was kanamycin, the detection limit was 0.1μg/mL, the quantitative limit was 0.2μg/mL. This method is rapid, sensitive and reproducible, and is suitable for the detection of kanamycin in this batch of unknown drugs.
Key words:  Kanamycin  Unknown drugs  UPLC-MS/MS

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