| 摘要: |
| 异噁唑啉类是一类新型抗寄生虫药物，氟雷拉纳（fluralaner）作为异噁唑啉类的成员，对节肢动物γ–氨基丁酸和L–谷氨酸门控氯通道具有选择性抑制作用，目前广泛用于治疗犬和猫的体外寄生虫。与其他类杀虫剂相比，氟雷拉纳具有操作简单、易吸收、安全、高效、长效以及良好的耐受性等特点。本文围绕氟雷拉纳的作用机制与药代动力学特征、临床研究现状以及临床安全性展开充分的总结与归纳。以期为氟雷拉纳在科研、消费以及应用范围等方面，提供有价值参考。 |
| 关键词: 氟雷拉纳 异噁唑啉类 安全性 药代动力学 |
| DOI： |
| 投稿时间：2021-08-16修订日期：2022-03-30 |
| 基金项目: |
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| Current status of research and application of the novel isoxazoline compound fluralaner |
|
| (Feed research institutechinese academy of agricultural sciences) |
| Abstract: |
| Fluralaner,a member of the isoxazolines, is a new class of antiparasitic drugs with selective inhibition of arthropod γ-aminobutyric acid and L-glutamate-gated chloride channels, and is now widely used for the treatment of ectoparasites in dogs and cats. Compared with other types of insecticides, fluralaner has the characteristics of simple operation, easy absorption, safety, high efficiency, long-lasting effect and good tolerance. In this paper, the mechanism of action and pharmacokinetic characteristics, the current status of clinical research and clinical safety of fluralaner are fully summarized. It is expected to provide a valuable reference for the research, consumption and application of fluralaner. |
| Key words: Fluralaner isoxazoline safety pharmacokinetics |
