| 摘要: |
| 利用数学建模分析兽药药代动力学历来已久。兽药药代动力学中应用数学建模和模拟分析可简化和加快兽药研发进程。非线性混合效应模型分析方法是兽药药代动力学建模和模拟的主要方法之一，该方法对临床合理用药、新药研发及评审更高效具有很大意义，同时阐明一些传统药动学无法回答的问题。本文综述了非线性混合效应模型在分析兽药药代动力学主要原理及应用进展，以期望非线性混合效应模型分析方法在我国新兽药研发与评审中应用提供积极有益的参考。 |
| 关键词: 非线性混合效应模型 兽药 药代动力学 |
| DOI： |
| 投稿时间：2021-10-28修订日期：2022-01-21 |
| 基金项目:山西省留学回国人员科技活动择优资助项目(20210012)；深圳市瑞鹏公益基金会与新瑞鹏宠物医疗集团有限公司共同资助瑞鹏公益基金会资助(RPJJ2020021)；山西省优秀博士来晋工作奖励(SXBYKY2021047) |
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| Research progress in analysis of veterinary drugs pharmacokinetics based on nonlinear mixed effects models |
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| (College of Veterinary Medicine, Shanxi Agricultural University) |
| Abstract: |
| Mathematical modeling has long been used to analyze pharmacokinetics of the veterinary drugs. Advances in mathematical modeling and simulation beyond pharmacokinetics have the potential to streamline and speed-up the veterinary drug research and development processes. The non-linear mixed effects (NLME) analysis method is one of the main methods for veterinary drug pharmacokinetic modeling and simulation. The research method of NLME has guiding significance for clinical rational medication, and facilitating new veterinary drug development and regulatory decision-making. This article reviews the main principles and application progress of nonlinear mixed-effects models in the analysis of veterinary drug pharmacokinetics. This article can be a valuable reference to those researchers and regulator reviewers who wish to adapt NLME studies into new veterinary drug development and drug approval processes in China. |
| Key words: Nonlinear mixed-effects models Veterinary drug Pharmacokinetics |
