| 摘要: |
| 为评价复方制剂清呼合剂在临床应用的安全性，试验通过对KM小鼠单次灌胃清呼合剂，观察试验小鼠出现的中毒症状、中毒程度、性质及死亡情况，评价受试药物毒性作用的性质。结果显示，KM小鼠经口灌服5000mg/kg剂量的清呼合剂，7天内未出现死亡、精神及行为异常，表明本品对KM小鼠的LD50大于5000mg/kg。根据急性毒性分级标准判定，本品属实际无毒类中兽药。 |
| 关键词: 清呼合剂 急性毒性试验 安全性评价 |
| DOI： |
| 投稿时间：2021-11-18修订日期：2022-03-07 |
| 基金项目:石家庄科技支撑计划项目“治疗鸡呼吸道疾病的国家三类新兽药的研制”（2021490162A） |
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| Acute Toxicity Test of Qinghu Mixture |
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| (The Corporation of Shijiazhuang Jiangshan Animal Pharmaceutical) |
| Abstract: |
| In order to evaluate the safety of the compound preparation Qinghu Mixture in clinical application, this experiment was conducted by giving a single gavage of Qinghu Mixture to KM mice to observe the symptoms of poisoning, the degree of poisoning, the nature and the death of the experimental mice, and evaluate the Test the nature of the drug"s toxic effects. The results showed that KM mice were orally administered with Qinghu mixture at a dose of 5000 mg/kg, and no death, mental or behavioral abnormalities occurred within 7 days, indicating that the LD50 of this product to KM mice was greater than 5000 mg/kg. According to the acute toxicity classification standard, this product belongs to the actual non-toxic Chinese veterinary medicine. |
| Key words: Qinghu Heji acute toxicity test safety evaluation |
