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非洲马瘟病毒VP7蛋白研究进展
张桂铭,张兵,张敏,宋亚芬,杨承槐
0
(中国兽医药品监察所)
摘要:
非洲马瘟(African horse sickness, AHS)是由非洲马瘟病毒(African horse sickness virus, AHSV)引起的一种主要感染马科动物、通过库蜢等昆虫传播的一类动物疫病。我国是世界动物卫生组织(WOAH)认可的非洲马瘟无疫国,随着非洲马瘟疫情在东南亚的传播,增大了疫情传入我国的风险。AHSV的血清群特异性蛋白VP7是病毒内衣壳蛋白的主要组成部分,在AHSV 9个血清型中高度保守,常作为ELISA检测的靶标蛋白,其对应的S7基因也常作为血清群特异性核酸检测的靶点。此外,VP7蛋白的自组装特点对于AHSV亚单位疫苗和病毒样颗粒疫苗(VLP)的研究有基础性作用。因此,VP7对AHSV检测、预防具有重要作用。本文综述了当前AHSV VP7蛋白研究的相关进展,以期为AHSV及其检测方法与疫苗研究等方面提供参考。
关键词:  AHSV  VP7  结构  诊断  疫苗
DOI:
投稿时间:2022-10-07修订日期:2023-04-21
基金项目:“十四五”国家重点研发计划“重大外来动物疫病阻断与防控技术研发项目”(2022YFD1800500);兽药行业公益性重点专项“非洲马瘟病毒毒种研究”(GY202030)
Research Progress on VP7 Protein of African Horse Sickness Virus
(China Institute of Veterinary Drug Control,Beijing,10081)
Abstract:
African horse sickness (AHS) is a kind of animal disease caused by African horse sickness virus (AHSV), which mainly infects equines and is transmitted by insects such as Culicoid. Our country is an African horse sickness-free country recognized by the World Organization for Animal Health (WOAH). With the spread of the African horse sickness in Southeast Asia, the risk of the epidemic spreading to our country has increased. The serogroup-specific protein VP7 of AHSV is the main component of the inner coat protein of the virus. It is highly conserved among the 9 serotypes of AHSV and is often used as the target protein for ELISA detection. Its corresponding S7 gene is also often used as a serogroup-specific nucleic acid detection target. In addition, the self-assembly characteristics of VP7 protein have a fundamental role in the research of subunit vaccines and virus-like particle vaccines(VLPs). Therefore, VP7 plays an important role in the detection and prevention of AHSV. This article reviews the current research progress of AHSV VP7 protein research, in order to provide references for AHSV and its detection methods and vaccine research.
Key words:  AHSV  VP7  structure  diagnose  vaccine

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