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硫酸头孢喹肟乳房注入剂中头孢喹肟含量HPLC通用性测定方法的建立
韩宁宁,彭文绣,王轩,赵晖,杨秀玉,戴青,赵富华
0
(中国兽医药品监察所)
摘要:
建立了适用于国内硫酸头孢喹肟乳房注入剂(泌乳期和干乳期)含量测定的通用性方法。采用与《中国兽药典》硫酸头孢喹肟原料含量测定一致的色谱条件,使用有机溶剂破乳后加入流动相超声的提取方法,保证了方法的一致性和适用性。方法验证结果显示,本方法专属性较强,准确度较高,重复性和耐用性良好,适用于对国内硫酸头孢喹肟乳房注入剂的含量测定,被收载入2020年版《中国兽药典》。
关键词:  硫酸头孢喹肟乳房注入剂(泌乳期和干乳期)  含量测定  通用性  破乳
DOI:
投稿时间:2022-10-20修订日期:2023-05-05
基金项目:农业行业(国家)标准项目兽药国家标准制修订计划(编号:2017H002)
Establishment of Universal HPLC Method for the Determination of Cefquinome in Cefquinome Sulfate Intramammary Infusion
(China Institute of Veterinary Drug Control)
Abstract:
A general method for the determination of cefquinome sulfate intramammary infusion (lactating cow and dry cow) was established. The chromatographic conditions consistent with the content determination of cefquinome sulfate raw material in Chinese Veterinary Pharmacopoeia, and the extraction method of adding mobile phase to ultrasound after demulsification with organic solvent ensured the consistency and applicability of the method. The validation results of the method showed that the specificity, accuracy, repeatability and durability of this method were strong, and it was suitable for the content determination of domestic cefquinome sulfate intramammary infusion. It was included in the Chinese Veterinary Pharmacopoeia (2020).
Key words:  cefquinome sulfate intramammary infusion (lactating cow and dry cow)  content determination  universality  demulsification

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