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不同来源白色念珠菌的基因型及耐药性分析
迟灵芝,毛红彦,李婧,王洪利
0
(山东畜牧兽医职业学院)
摘要:
为了研究不同来源白色念珠菌的基因型及耐药性情况,试验对患病鸡、鸭、鹅进行白色念珠菌的分离,用特异性引物扩增分离株的25S rDNA分析其基因型,用抗真菌药物伊曲康唑、制霉菌素、两性霉素B等对分离株进行耐药性分析。结果显示:从鸡、鸭、鹅中分离得到三株白色念珠菌CaJ、CaY和CaE,其基因型分别为 A型、A型和B型,耐药性试验结果显示三株分离株对制霉菌素和两性霉素B均表现出了较高的敏感性,但对其它药物表现出不同程度的耐药性。说明部分药物临床中可能使用过多,来自不同家禽的白色念珠菌在耐药性方面有所不同。
关键词:  白色念珠菌  基因型  耐药性  分离  抗真菌药物
DOI:
投稿时间:2023-11-07修订日期:2024-05-13
基金项目:
genotypes and drug resistance analysis of candida albicans with different sources
(Shandong Vocational Animal Science and Veterinary College)
Abstract:
To study the genotypes and drug resistance of Candida albicans with different sources,Candida albicans were isolated and identified from diseased chicken、duck and goose,specific primers were used to amplify the 25S rDNA of Candida albicans to analyze the genotypes,and antifungal drugs such as itraconazole,nystatin and amphotericin B were used to analyze the drug resistance of the isolates. The results showed that three strains of Candida albicans CaJ、CaY and CaE were isolated from chicken,duck and goose,and their genotypes were type A,type A and type B,respectively. The drug resistance test results showed that the three isolates showed high sensitivity to nystin and amphotericin B,but showed different resistance to other drugs. These results indicated that some drugs may be overused in clinical,Candida albicans from different poultry varies in terms of resistance.
Key words:  Candida albicans  genotype  drug resistance  isolate  antifungal drugs[基金项目:潍坊市科技惠民计划项目(2020KJHM23)  潍坊市科技发展计划项目(2021GX035)

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