| 摘要: |
| 为了合成一种有抑菌活性的新喹喔啉衍生物，即3-甲基-2-乙酰苯腙喹喔啉1，4-二氧物，以邻硝基苯胺为基本原料，经氧化反应，Beirut反应和加成缩合反应，制得目标产物，产率73.5%。用红外光谱法（IR）、质谱法（MS）和核磁共振谱法（NMR）对产物结构进行表征，证明合成产物为目标产物。并通过抑菌测试发现，新化合物对大肠杆菌、枯草杆菌、金葡萄球菌和青霉菌均有明显的抑菌活性。试验结果将为今后更好地开展喹喔啉及其衍生物的抗菌药用研究奠定基础。 |
| 关键词: 喹喔啉 合成 结构表征 抑菌测试 |
| DOI： |
| 投稿时间：2016-11-24修订日期：2017-03-20 |
| 基金项目:烟台市科技发展计划项目（2012ZH247） |
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| Study on the Synthesis and Bacteriostasis of 3-Methyl-2-Acetyl phenylhydrazone Quinoxaline 1,4-Dioxide |
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| (China Agricultural University(Yantai)) |
| Abstract: |
| In order to synthesize a new quinoxaline derivative with antibacterial activity,3-methyl-2-acetylphenylhydrazone quinoxaline 1,4-dioxygen,using o-nitroaniline as raw material, and aquire the target derivatives in a yield of 73.5% though Oxidation reaction、Beirut reaction and addition condensation reaction.It was proved that the new compound synthesized in experiment were target compound by infrared spectroscopy (IR), mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). The antibacterial results showed that the 3-methyl-2-acetyl phenylhydrazone quinoxaline 1,4-dioxane had obvious inhibitory activity against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Penicillium.The experimental results will lay the foundation for the future research of quinoxaline and its derivatives. |
| Key words: quinoxaline synthesis structure characterized Antibacterial test |
